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KMID : 1161420140170050618
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Journal of Medicinal Food
2014 Volume.17 No. 5 p.618 ~ p.624
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Effects of an Orabase Formulation with Ethanolic Extract of Malva sylvestris L. in Oral Wound Healing in Rats
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Kovalik Ana Cristina
Bisetto Paula
Pochapski Marcia Thais
Campagnoli Eduardo Baulm
Pilatti Gibson Luiz
Santos Fabio Andre
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Abstract
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Malva sylvestris L. is widely used in medicine for treatment of inflammatory processes. The plant has anti-inflammatory properties due to substances such as mucilage, flavonoids, and tannins. A mouthwash with leaves from the plant can be used for the treatment of wounds in the oral mucosa. The aim of this study was to assess the wound healing effect of Malva sylvestris L. on a palate mucosa wound in rats. After intraperitoneal anesthesia, a 4-mm-diameter excisional wound was made in the center of the palatal mucosa of 136 rats, using a punch-out biopsy tool. Eight animals were used as baseline wound. The remaining rats were divided into four groups: CO, control; OB, orabase vehicle; CX, 2% chlorhexidine; and MA, 20% Malva in orabase. At 24?h postoperatively, the animals were immobilized without anesthetic to apply 25?mg of each substance twice a day, totaling 50?mg daily. The wound areas were measured photographically and the reepithelialization rates were determined histologically (%) after 0, 3, 7, 15, and 21 days. The data were analyzed by ANOVA and Tukey post hoc test. Similar healing pattern was observed among the groups (P>.05; ANOVA). According to the methodology, Malva sylvestris L. extract had no effect on wound healing in the palatal mucosa of rats.
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KEYWORD
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herbal medicine, medicinal food, mucosa, palate, phytotherapy, oral ulcer, rat, wound healing
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